Foxa2 Controls Pdx1 Gene Expression in Pancreatic -Cells In Vivo
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چکیده
منابع مشابه
Foxa2 Controls Pdx1 Gene Expression in Pancreatic -Cells In Vivo
Differentiation of early foregut endoderm into pancreatic endocrine and exocrine cells depends on a cascade of gene activation events controlled by various transcription factors. Prior in vitro analysis has suggested that the forkhead/winged helix transcription factor Foxa2 (formerly HNF-3 ) is a major upstream regulator of Pdx1, a homeobox gene essential for pancreatic development. Pdx1 is als...
متن کاملFoxa2 and Pdx1 cooperatively regulate postnatal maturation of pancreatic β-cells
OBJECTIVE The transcription factors (TF) Foxa2 and Pdx1 are key regulators of beta-cell (β-cell) development and function. Mutations of these TFs or their respective cis-regulatory consensus binding sites have been linked to maturity diabetes of the young (MODY), pancreas agenesis, or diabetes susceptibility in human. Although Foxa2 has been shown to directly regulate Pdx1 expression during mou...
متن کاملThe diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in mice.
Heterozygous mutations in the gene encoding the pancreatic homeodomain transcription factor pancreatic duodenal homeobox 1 (PDX1) are associated with maturity onset diabetes of the young, type 4 (MODY4) and type 2 diabetes. Pdx1 governs the early embryonic development of the pancreas and the later differentiation of the insulin-producing islet beta cells of the endocrine compartment. We derived...
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Somatostatin is a peptide synthesized in the pancreatic islets, nervous system, gastrointestinal tract, and thyroid gland. Factors that control islet cell-specific expression of the somatostatin gene were analyzed by expression of fusion genes consisting of 5‘ rat somatostatin gene sequences linked to coding sequences of the reporter genes, bacterial chloramphenicol acetyltransferase, and human...
متن کاملDynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development.
The onset of pancreas development in the foregut endoderm is marked by activation of the homeobox gene Pdx1 (IPF1). Pdx1 is essential for the expansion of the pancreatic primordium and the development of endocrine islets. The control of Pdx1 expression has been only partially elucidated. We demonstrate here that the winged-helix transcription factors Foxa1 and Foxa2 co-occupy multiple regulator...
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ژورنال
عنوان ژورنال: Diabetes
سال: 2002
ISSN: 0012-1797,1939-327X
DOI: 10.2337/diabetes.51.8.2546